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Flk-1/Flt-4 (phospho Tyr1054/Y1063) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60996

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human VEGFR2 around the phosphorylation site of Tyr1054. AA range:1020-1069

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    KDR/FLT4

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using VEGFR2 (Phospho-Tyr1054) Antibody. The picture on the right is blocked with the phospho peptide.

  • Background:

    kinase insert domain receptor(KDR) Homo sapiens Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009],

  • Protein Name:

    Vascular endothelial growth factor receptor 2/3

  • Human Gene Id:

    3791/2324

  • Human Swiss Prot No:

    P35968/P35916

  • Mouse Gene Id:

    14257

  • Rat Gene Id:

    25589/114110

  • Rat Swiss Prot No:

    O08775/Q91ZT1

  • Specificity:

    Phospho-Flk-1/Flt-4 (Y1054/Y1063) Polyclonal Antibody detects endogenous levels of Flk-1/Flt-4 protein only when phosphorylated at Y1054/Y1063.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    KDR; FLK1; VEGFR2; Vascular endothelial growth factor receptor 2; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1; CD antigen CD309; FLT4; VEGFR3; Vascular endothelial growth

  • MolecularWeight(Da):

    151527

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with MYOF (By similarity). Interacts with SHB; upon VEGF activation. Interacts with HIV-1 Tat.,

  • Subcellular Location:

    extracellular region,nucleus,endosome,early endosome,endoplasmic reticulum,Golgi apparatus,plasma membrane,integral component of plasma membrane,integral component of membrane,cytoplasmic, membrane-bounded vesicle,cell junction,

  • Expression:

    Aorta endothelial cell,Lung,Umbilical vein,

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Catalog Number

  • Amount:100ul
  • Price:225$

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Flk-1/Flt-4 (phospho Tyr1054/Y1063) Polyclonal Antibody | EnoGene Biotech Co. Ltd