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PDGFR-α (phospho Tyr754) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60993

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human PDGFR alpha around the phosphorylation site of Tyr754. AA range:721-770

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    PDGFRA

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using PDGFR alpha (Phospho-Tyr754) Antibody

  • Background:

    platelet derived growth factor receptor alpha(PDGFRA) Homo sapiens This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012],

  • Protein Name:

    Platelet-derived growth factor receptor alpha

  • Human Gene Id:

    5156

  • Human Swiss Prot No:

    P16234

  • Mouse Gene Id:

    18595

  • Mouse Swiss Prot No:

    P26618

  • Rat Gene Id:

    25267

  • Rat Swiss Prot No:

    P20786

  • Specificity:

    Phospho-PDGFR-α (Y754) Polyclonal Antibody detects endogenous levels of PDGFR-α protein only when phosphorylated at Y754.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    PDGFRA; PDGFR2; RHEPDGFRA; Platelet-derived growth factor receptor alpha; PDGF-R-alpha; PDGFR-alpha; Alpha platelet-derived growth factor receptor; Alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD14

  • MolecularWeight(Da):

    122670

  • Observed Band(KD):

    122

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage.,function:Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer, and heterodimer with PDGFRB. Interacts with the SH2 domain of SHB via phosphorylated Tyr-720 (By similarity). Interacts with the S

  • Subcellular Location:

    nucleus,cytoplasm,plasma membrane,integral component of plasma membrane,membrane,intrinsic component of plasma membrane,protein complex,

  • Expression:

    Blood,Brain,Colon tumor,Eosinophil,Foreskin,Lung,Placenta,T,

  • Immunohistochemistry analysis of paraffin-embedded human brain, using PDGFR alpha (Phospho-Tyr754) Antibody. The picture on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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