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Plk (phospho Thr210) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60964

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human PLK1 around the phosphorylation site of Thr210. AA range:176-225

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    PLK1

  • Dilution:

    WB 1:500-2000 ,Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Western blot analysis of 293 using p-Plk (T210) antibody.

  • Background:

    polo like kinase 1(PLK1) Homo sapiens The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015],

  • Protein Name:

    Serine/threonine-protein kinase PLK1

  • Human Gene Id:

    5347

  • Human Swiss Prot No:

    P53350

  • Mouse Gene Id:

    18817

  • Mouse Swiss Prot No:

    Q07832

  • Rat Gene Id:

    25515

  • Rat Swiss Prot No:

    Q62673

  • Specificity:

    Phospho-Plk (T210) Polyclonal Antibody detects endogenous levels of Plk protein only when phosphorylated at T210.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    PLK1; PLK; Serine/threonine-protein kinase PLK1; Polo-like kinase 1; PLK-1; Serine/threonine-protein kinase 13; STPK13

  • MolecularWeight(Da):

    68255

  • Observed Band(KD):

    70

  • Function:

    catalytic activity:ATP + a protein = ADP + a phosphoprotein.,developmental stage:Accumulates to a maximum during the G2 and M phases, declines to a nearly undetectable level following mitosis and throughout G1 phase, and then begins to accumulate again during S phase.,enzyme regulation:Activated by serine and threonine phosphorylation.,function:Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis.,induction:By growth-stimulating agents.,PTM:Autophosphorylation and phosphorylation of Ser-137 are not significant events during activation of PLK1 in M phase.,PTM:Catalytic activity is enhanced by phosphorylation of Thr-210 and/or S

  • Subcellular Location:

    kinetochore,chromatin,synaptonemal complex,spindle pole,condensed nuclear chromosome outer kinetochore,nucleus,nucleoplasm,nucleolus,cytoplasm,centrosome,spindle,cytosol,spindle microtubule,microtubule cyto

  • Expression:

    Brain,Colon,Lung,Placenta,

  • Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using PLK1 (Phospho-Thr210) Antibody

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Catalog Number

  • Amount:100ul
  • Price:225$

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Plk (phospho Thr210) Polyclonal Antibody | EnoGene Biotech Co. Ltd