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PKAα cat (phospho Ser338) Polyclonal Antibody
Datasheet
Catalog Number:
E20-60963Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
Synthesized phospho-peptide around the phosphorylation site of human PKAα cat (phospho Ser338)Source:
Polyclonal, RabbitGene Name:
PRKACADilution:
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.Background:
protein kinase cAMP-activated catalytic subunit alpha(PRKACA) Homo sapiens This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. AlternProtein Name:
cAMP-dependent protein kinase catalytic subunit alphaHuman Gene Id:
5566Human Swiss Prot No:
P17612Mouse Gene Id:
18747Mouse Swiss Prot No:
P05132Rat Swiss Prot No:
P27791Specificity:
Phospho-PKAα cat (S338) Polyclonal Antibody detects endogenous levels of PKAα cat protein only when phosphorylated at S338.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
PRKACA; PKACA; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alphaMolecularWeight(Da):
40590Function:
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by cAMP.,function:Phosphorylates a large number of substrates in the cytoplasm and the nucleus.,PTM:Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm.,subunit:A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP caSubcellular Location:
acrosomal vesicle,nucleus,nucleoplasm,mitochondrion,centrosome,cytosol,plasma membrane,cAMP-dependent protein kinase complex,membrane,nuclear speck,motile cilium,nucleotide-activated protein kinasExpression:
Amnion,Epithelium,Eye,Sperm,Testis,Thalamus,
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