Adducin α (phospho Thr445) Polyclonal Antibody

Name: Adducin α (phospho Thr445) Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-60955
Price: 225 USD
Availability: InStock

E20-60955Cite ID: EN0049881Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight80955Da

Protein NameAlpha-adducin

Human Gene Id118

Human Swiss Prot NoP35611

Mouse Gene Id11518

Mouse Swiss Prot NoQ9QYC0

Rat Gene Id24170

Rat Swiss Prot NoQ63028

SpecificityPhospho-Adducin α (T445) Polyclonal Antibody detects endogenous levels of Adducin α protein only when phosphorylated at T445

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameADD1; ADDA; Alpha-adducin; Erythrocyte adducin subunit alpha

Functionalternative products:Additional isoforms seem to exist,domain:Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.,function:Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.,PTM:The N-terminus is blocked.,similarity:Belongs to the aldolase class II family. Adducin subfamily.,subunit:Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. Binds ROCK1.,tissue specificity:Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.,

Subcellular Locationnucleus,nucleoplasm,cytosol,cytoskeleton,plasma membrane,cell-cell adherens junction,focal adhesion,F-actin capping protein complex,

ExpressionBrain cortex,Epithelium,Muscle,Platelet,Reticulocyte,Testis,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from human ADD1 around the phosphorylation site of Thr445. AA range:411-460

Gene NameADD1

DilutionImmunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

Backgroundadducin 1(ADD1) Homo sapiens Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-60955-Conjugate. Price: $485 / Size: 100μl.

E20-60955-FITC$485 / 100μlE20-60955-Biotin$485 / 100μlE20-60955-HRP$485 / 100μlE20-60955-AP$485 / 100μlE20-60955-AF350$485 / 100μlE20-60955-AF405M$485 / 100μlE20-60955-AF488$485 / 100μlE20-60955-AF514$485 / 100μlE20-60955-AF532$485 / 100μlE20-60955-AF555$485 / 100μlE20-60955-AF568$485 / 100μlE20-60955-AF405S$485 / 100μlE20-60955-AF405L$485 / 100μlE20-60955-AF546$485 / 100μlE20-60955-AF594$485 / 100μlE20-60955-AF610$485 / 100μlE20-60955-AF635$485 / 100μlE20-60955-AF647$485 / 100μlE20-60955-AF680$485 / 100μlE20-60955-AF700$485 / 100μlE20-60955-AF750$485 / 100μlE20-60955-AF790$485 / 100μlE20-60955-APC$485 / 100μlE20-60955-PE$485 / 100μlE20-60955-Cy3$485 / 100μlE20-60955-Cy5$485 / 100μlE20-60955-Cy5.5$485 / 100μlE20-60955-Cy7$485 / 100μlE20-60955-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.