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Trk A (phospho Tyr791) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60954

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Trk A around the phosphorylation site of Tyr791. AA range:747-796

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    NTRK1

  • Dilution:

    Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Immunohistochemical analysis of paraffin-embedded Human breast cancer. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

  • Background:

    neurotrophic receptor tyrosine kinase 1(NTRK1) Homo sapiens This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008],

  • Protein Name:

    High affinity nerve growth factor receptor

  • Human Gene Id:

    4914

  • Human Swiss Prot No:

    P04629

  • Mouse Swiss Prot No:

    Q3UFB7

  • Specificity:

    Phospho-Trk A (Y791) Polyclonal Antibody detects endogenous levels of Trk A protein only when phosphorylated at Y791.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    NTRK1; MTC; TRK; TRKA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A;

  • MolecularWeight(Da):

    87497

  • Observed Band(KD):

    140-180

  • Function:

    alternative products:Both isoforms have similar biological properties,catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Chromosomal aberrations involving NTRK1 are a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Intrachromosomal rearrangement that links the protein kinase domain of NTRK1 to the 5'-end of the TPR gene forms the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reacting with antibodies against the C-terminus of the NTRK1 protein.,disease:Chromosomal aberrations involving NTRK1 are a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Translocation t(1;3)(q21;q11) with TFG generates the TRKT3 (TRK-T3) transcript by fusing TFG to the 3'-end of NTRK1; a rearrangement with TPM3 gen

  • Subcellular Location:

    endosome,early endosome,late endosome,plasma membrane,integral component of plasma membrane,cell surface,axon,dendrite,cytoplasmic vesicle,early endosome membrane,late endosome membrane,neuronal cell body,

  • Expression:

    Brain,Colon,Peripheral blood,

  • Immunohistochemistry analysis of paraffin-embedded human brain, using Trk A (Phospho-Tyr791) Antibody. The picture on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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Trk A (phospho Tyr791) Polyclonal Antibody | EnoGene Biotech Co. Ltd