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Cell Signal Transduction Research Antibodies
p57 (phospho Thr310) Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight32177 Da
Protein NameCyclin-dependent kinase inhibitor 1C
Human Gene Id1028
Human Swiss Prot NoP49918
Mouse Gene Id12577
Mouse Swiss Prot NoP49919
SpecificityPhospho-p57 (T310) Polyclonal Antibody detects endogenous levels of p57 protein only when phosphorylated at T310.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCDKN1C; KIP2; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; p57Kip2
Observed Band(KD)32
Functiondisease:Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.,disease:Defects in CDKN1C are involved in tumor formation.,function:Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels ar
Subcellular Locationnucleus,cytoplasm,
ExpressionEmbryo,Placenta,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human p57 Kip2 around the phosphorylation site of Thr310. AA range:267-316
Gene NameCDKN1C
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundcyclin dependent kinase inhibitor 1C(CDKN1C) Homo sapiens This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-60927-Conjugate. Price: $485 / Size: 100μl.
E20-60927-FITC$485 / 100μlE20-60927-Biotin$485 / 100μlE20-60927-HRP$485 / 100μlE20-60927-AP$485 / 100μlE20-60927-AF350$485 / 100μlE20-60927-AF405M$485 / 100μlE20-60927-AF488$485 / 100μlE20-60927-AF514$485 / 100μlE20-60927-AF532$485 / 100μlE20-60927-AF555$485 / 100μlE20-60927-AF568$485 / 100μlE20-60927-AF405S$485 / 100μlE20-60927-AF405L$485 / 100μlE20-60927-AF546$485 / 100μlE20-60927-AF594$485 / 100μlE20-60927-AF610$485 / 100μlE20-60927-AF635$485 / 100μlE20-60927-AF647$485 / 100μlE20-60927-AF680$485 / 100μlE20-60927-AF700$485 / 100μlE20-60927-AF750$485 / 100μlE20-60927-AF790$485 / 100μlE20-60927-APC$485 / 100μlE20-60927-PE$485 / 100μlE20-60927-Cy3$485 / 100μlE20-60927-Cy5$485 / 100μlE20-60927-Cy5.5$485 / 100μlE20-60927-Cy7$485 / 100μlE20-60927-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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