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Cell Signal Transduction Research Antibodies
HDAC6 (phospho Ser22) Polyclonal Antibody
Human;Mouse
WB;IHC-p;IF/ICC;ELISA
Polyclonal, Rabbit,IgG
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight131431Da
Protein NameHistone deacetylase 6
Human Gene Id10013
Human Swiss Prot NoQ9UBN7
Mouse Gene Id15185
Mouse Swiss Prot NoQ9Z2V5
SpecificityPhospho-HDAC6 (S22) Polyclonal Antibody detects endogenous levels of HDAC6 protein only when phosphorylated at S22.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameHDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6
Observed Band(KD)131
Functioncatalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.,PTM:Sumoylated in vitro.,PTM:Ubiquitinated. Its polyubiquitination however does not lead to its degradation.,similarity:Belongs to the histone deacetylase family. Type 2 subfamily.,similarity:Contains 1 UBP-type zinc finger.,subcellular location:It is mainly cytoplasmic, where it is associated with microtubules
Subcellular LocationCytoplasm . Cytoplasm, cytoskeleton . Nucleus . Perikaryon . Cell projection, dendrite . Cell projection, axon . It is mainly cytoplasmic, where it is associated with microtubules. .
ExpressionBrain,Epithelium,Kidney,Muscle,Ovary,Placenta,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human HDAC6 around the phosphorylation site of Ser22. AA range:7-56
Gene NameHDAC6
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
BackgroundHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-60922-Conjugate. Price: $485 / Size: 100μl.
E20-60922-FITC$485 / 100μlE20-60922-Biotin$485 / 100μlE20-60922-HRP$485 / 100μlE20-60922-AP$485 / 100μlE20-60922-AF350$485 / 100μlE20-60922-AF405M$485 / 100μlE20-60922-AF488$485 / 100μlE20-60922-AF514$485 / 100μlE20-60922-AF532$485 / 100μlE20-60922-AF555$485 / 100μlE20-60922-AF568$485 / 100μlE20-60922-AF405S$485 / 100μlE20-60922-AF405L$485 / 100μlE20-60922-AF546$485 / 100μlE20-60922-AF594$485 / 100μlE20-60922-AF610$485 / 100μlE20-60922-AF635$485 / 100μlE20-60922-AF647$485 / 100μlE20-60922-AF680$485 / 100μlE20-60922-AF700$485 / 100μlE20-60922-AF750$485 / 100μlE20-60922-AF790$485 / 100μlE20-60922-APC$485 / 100μlE20-60922-PE$485 / 100μlE20-60922-Cy3$485 / 100μlE20-60922-Cy5$485 / 100μlE20-60922-Cy5.5$485 / 100μlE20-60922-Cy7$485 / 100μlE20-60922-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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