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Crk-L (phospho Tyr207) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60869

  • Amount:

    100ul

  • Molecular Weight:

    33777 Da

  • Applications:

    WB;IHC-p;IF/ICC;ELISA

  • Reactivity:

    Human;Mouse;Rat;Monkey

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human CrkL around the phosphorylation site of Tyr207. AA range:173-222

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Phospho-Crk-LPolyclonal Antibody

  • Gene Name:

    CRKL

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

  • Background:

    This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009],

  • Protein Name:

    Crk-like protein

  • Human Gene Id:

    1399

  • Human Swiss Prot No:

    P46109

  • Mouse Gene Id:

    12929

  • Mouse Swiss Prot No:

    P47941

  • Rat Gene Id:

    1.00911e+008

  • Rat Swiss Prot No:

    Q5U2U2

  • Specificity:

    Phospho-Crk-L (Y207) Polyclonal Antibody detects endogenous levels of Crk-L protein only when phosphorylated at Y207.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CRKL; Crk-like protein

  • Observed Band(KD):

    39

  • Function:

    function:May mediate the transduction of intracellular signals.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4.,

  • Subcellular Location:

    endosome,cytosol,cell-cell adherens junction,extracellular exosome,

  • Expression:

    Skin,Spleen,

  • Western blot analysis of lysates from COS7 cells, using CrkL Antibody. The lane on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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Crk-L (phospho Tyr207) Polyclonal Antibody | EnoGene Biotech Co. Ltd