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Cell Signal Transduction Research Antibodies
Vav3 (phospho Tyr173) Polyclonal Antibody(phospho Tyr749/681) Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight97776 Da
Protein NameGuanine nucleotide exchange factor VAV3
Human Gene Id10451
Human Swiss Prot NoQ9UKW4
Mouse Gene Id57257
Mouse Swiss Prot NoQ9R0C8
SpecificityPhospho-Vav3 (Y173) Polyclonal Antibody detects endogenous levels of Vav3 protein only when phosphorylated at Y173.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameVAV3; Guanine nucleotide exchange factor VAV3; VAV-3
Observed Band(KD)100
Functionfunction:Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with the PH domain of APS.,
Subcellular Locationintracellular,cytosol,plasma membrane,extracellular exosome,
ExpressionColon carcinoma,Mammary gland,Placenta,Trachea,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized phospho-peptide around the phosphorylation site of human Vav3 (phospho Tyr173)
Gene NameVAV3
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Backgroundvav guanine nucleotide exchange factor 3(VAV3) Homo sapiens This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-60839-Conjugate. Price: $485 / Size: 100μl.
E20-60839-FITC$485 / 100μlE20-60839-Biotin$485 / 100μlE20-60839-HRP$485 / 100μlE20-60839-AP$485 / 100μlE20-60839-AF350$485 / 100μlE20-60839-AF405M$485 / 100μlE20-60839-AF488$485 / 100μlE20-60839-AF514$485 / 100μlE20-60839-AF532$485 / 100μlE20-60839-AF555$485 / 100μlE20-60839-AF568$485 / 100μlE20-60839-AF405S$485 / 100μlE20-60839-AF405L$485 / 100μlE20-60839-AF546$485 / 100μlE20-60839-AF594$485 / 100μlE20-60839-AF610$485 / 100μlE20-60839-AF635$485 / 100μlE20-60839-AF647$485 / 100μlE20-60839-AF680$485 / 100μlE20-60839-AF700$485 / 100μlE20-60839-AF750$485 / 100μlE20-60839-AF790$485 / 100μlE20-60839-APC$485 / 100μlE20-60839-PE$485 / 100μlE20-60839-Cy3$485 / 100μlE20-60839-Cy5$485 / 100μlE20-60839-Cy5.5$485 / 100μlE20-60839-Cy7$485 / 100μlE20-60839-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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