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Presenilin 1 (phospho Ser357) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60831

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human PSEN1 around the phosphorylation site of Ser357. AA range:323-372

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    PSEN1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human brain, using PSEN1 (Phospho-Ser357) Antibody. The picture on the right is blocked with the phospho peptide.

  • Background:

    presenilin 1(PSEN1) Homo sapiens Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008],

  • Protein Name:

    Presenilin-1

  • Human Gene Id:

    5663

  • Human Swiss Prot No:

    P49768

  • Specificity:

    Phospho-Presenilin 1 (S357) Polyclonal Antibody detects endogenous levels of Presenilin 1 protein only when phosphorylated at S357.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182

  • MolecularWeight(Da):

    52668

  • Observed Band(KD):

    43

  • Function:

    disease:Defects in PSEN1 are a cause of Alzheimer disease type 3 (AD3) [MIM:607822]. AD3 is a familial early-onset form of Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitve abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.,disease:Defects in PSEN1 are a cause of frontotemporal dementia [MIM:600274].,domain:The PAL motif is required for normal active site conformation.,fun

  • Subcellular Location:

    Golgi membrane,kinetochore,intracellular,nucleus,nuclear outer membrane,mitochondrion,mitochondrial inner membrane,lysosomal membrane,endoplasmic reticulum,endoplasmic reticulum membrane,smooth endoplasmic reticulum,rough endoplasmic re

  • Expression:

    Blood,Brain,Epithelium,Human lung,Megakaryocyte,Platelet,Skin,

  • Western blot analysis of lysates from RAW264.7 cells treated with UV 5', using PSEN1 (Phospho-Ser357) Antibody. The lane on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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