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Cell Signal Transduction Research Antibodies
GRIP-1 (phospho Ser736) Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight180
Protein NameNuclear receptor coactivator 2
Human Gene Id10499
Human Swiss Prot NoQ15596
Mouse Swiss Prot NoQ61026
SpecificityPhospho-GRIP-1 (S736) Polyclonal Antibody detects endogenous levels of GRIP-1 protein only when phosphorylated at S736.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNCOA2; BHLHE75; TIF2; Nuclear receptor coactivator 2; NCoA-2; Class E basic helix-loop-helix protein 75; bHLHe75; Transcriptional intermediary factor 2; hTIF2
Functiondisease:Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3/MOZ and the C-terminus part of NCOA2/TIF2. MYST3-NCOA2 binds to CREBBP and disrupts its function in transcription activation.,domain:Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently.,domain:Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant.,domain:The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding.,function:Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Requi
Subcellular Locationnucleus,nucleoplasm,cytoplasm,
ExpressionEpithelium,Placenta,Spinal cord,Testis,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human NCoA2 around the phosphorylation site of Ser736. AA range:702-751
Gene NameNCOA2
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Backgroundnuclear receptor coactivator 2(NCOA2) Homo sapiens The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
Conjugated Antibody
This product is also available conjugated. Format: E20-60825-Conjugate. Price: $485 / Size: 100μl.
E20-60825-FITC$485 / 100μlE20-60825-Biotin$485 / 100μlE20-60825-HRP$485 / 100μlE20-60825-AP$485 / 100μlE20-60825-AF350$485 / 100μlE20-60825-AF405M$485 / 100μlE20-60825-AF488$485 / 100μlE20-60825-AF514$485 / 100μlE20-60825-AF532$485 / 100μlE20-60825-AF555$485 / 100μlE20-60825-AF568$485 / 100μlE20-60825-AF405S$485 / 100μlE20-60825-AF405L$485 / 100μlE20-60825-AF546$485 / 100μlE20-60825-AF594$485 / 100μlE20-60825-AF610$485 / 100μlE20-60825-AF635$485 / 100μlE20-60825-AF647$485 / 100μlE20-60825-AF680$485 / 100μlE20-60825-AF700$485 / 100μlE20-60825-AF750$485 / 100μlE20-60825-AF790$485 / 100μlE20-60825-APC$485 / 100μlE20-60825-PE$485 / 100μlE20-60825-Cy3$485 / 100μlE20-60825-Cy5$485 / 100μlE20-60825-Cy5.5$485 / 100μlE20-60825-Cy7$485 / 100μlE20-60825-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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