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MEF-2C (phospho Ser396) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60822

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human MEF2C around the phosphorylation site of Ser396. AA range:362-411

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    MEF2C

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human brain, using MEF2C (Phospho-Ser396) Antibody. The picture on the right is blocked with the phospho peptide.

  • Background:

    myocyte enhancer factor 2C(MEF2C) Homo sapiens This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010],

  • Protein Name:

    Myocyte-specific enhancer factor 2C

  • Human Gene Id:

    4208

  • Human Swiss Prot No:

    Q06413

  • Mouse Gene Id:

    17260

  • Mouse Swiss Prot No:

    Q8CFN5

  • Specificity:

    Phospho-MEF-2C (S396) Polyclonal Antibody detects endogenous levels of MEF-2C protein only when phosphorylated at S396.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MEF2C; Myocyte-specific enhancer factor 2C

  • MolecularWeight(Da):

    51221

  • Observed Band(KD):

    51

  • Function:

    alternative products:Additional isoforms seem to exist,developmental stage:Expression is highest during the early stages of postnatal development, at later stages levels greatly decrease.,domain:The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity.,function:Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.,PTM:Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation.,PTM:Phosphorylation on Se

  • Subcellular Location:

    nucleus,nucleoplasm,cytoplasm,cytosol,nuclear speck,intracellular membrane-bounded organelle,protein complex,postsynapse,

  • Expression:

    Fetal brain,Muscle,Skeletal muscle,

  • Western blot analysis of lysates from NIH/3T3 cells treated with starved 24h, using MEF2C (Phospho-Ser396) Antibody. The lane on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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MEF-2C (phospho Ser396) Polyclonal Antibody | EnoGene Biotech Co. Ltd