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Cell Signal Transduction Research Antibodies
VE-Cadherin (phospho Tyr731) Polyclonal Antibody
Human;Mouse
WB;IHC-p;IF(paraffin section);ELISA
Polyclonal, Rabbit,IgG
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight87516Da
Protein NameCadherin-5
Human Gene Id1003
Human Swiss Prot NoP33151
Mouse Gene Id12562
Mouse Swiss Prot NoP55284
SpecificityPhospho-VE-Cadherin (Y731) Polyclonal Antibody detects endogenous levels of VE-Cadherin protein only when phosphorylated at Y731.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCDH5; Cadherin-5; 7B4 antigen; Vascular endothelial cadherin; VE-cadherin; CD antigen CD144
Observed Band(KD)130
Functionfunction:Cadherins are calcium dependent cell adhesion proteins.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.,similarity:Contains 5 cadherin domains.,subcellular location:Found at cell-cell boundaries and probably at cell-matrix boundaries.,tissue specificity:Endothelial tissues and brain.,
Subcellular LocationCell junction . Cell membrane ; Single-pass type I membrane protein . Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. .
ExpressionEndothelial tissues and brain.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human VE-Cadherin around the phosphorylation site of Tyr731. AA range:697-746
Gene NameCDH5
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
BackgroundThis gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-60808-Conjugate. Price: $485 / Size: 100μl.
E20-60808-FITC$485 / 100μlE20-60808-Biotin$485 / 100μlE20-60808-HRP$485 / 100μlE20-60808-AP$485 / 100μlE20-60808-AF350$485 / 100μlE20-60808-AF405M$485 / 100μlE20-60808-AF488$485 / 100μlE20-60808-AF514$485 / 100μlE20-60808-AF532$485 / 100μlE20-60808-AF555$485 / 100μlE20-60808-AF568$485 / 100μlE20-60808-AF405S$485 / 100μlE20-60808-AF405L$485 / 100μlE20-60808-AF546$485 / 100μlE20-60808-AF594$485 / 100μlE20-60808-AF610$485 / 100μlE20-60808-AF635$485 / 100μlE20-60808-AF647$485 / 100μlE20-60808-AF680$485 / 100μlE20-60808-AF700$485 / 100μlE20-60808-AF750$485 / 100μlE20-60808-AF790$485 / 100μlE20-60808-APC$485 / 100μlE20-60808-PE$485 / 100μlE20-60808-Cy3$485 / 100μlE20-60808-Cy5$485 / 100μlE20-60808-Cy5.5$485 / 100μlE20-60808-Cy7$485 / 100μlE20-60808-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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