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FRS2 (phospho Tyr436) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60805

  • Amount:

    100ul

  • Molecular Weight:

    57528 Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Monkey

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human FRS2 around the phosphorylation site of Tyr436. AA range:402-451

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Phospho-FRS2 Polyclonal Antibody

  • Gene Name:

    FRS2

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Background:

    function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,

  • Protein Name:

    Fibroblast growth factor receptor substrate 2

  • Human Gene Id:

    10818

  • Human Swiss Prot No:

    Q8WU20

  • Mouse Gene Id:

    327826

  • Mouse Swiss Prot No:

    Q8C180

  • Specificity:

    Phospho-FRS2 (Y436) Polyclonal Antibody detects endogenous levels of FRS2 protein only when phosphorylated at Y436.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    FRS2; Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1

  • Observed Band(KD):

    65

  • Function:

    function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and t

  • Subcellular Location:

    Endomembrane system. Cytoplasmic, membrane-bound.

  • Expression:

    Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

  • Western Blot analysis of COS cells using Phospho-FRS2 Polyclonal Antibody

  • Immunohistochemistry analysis of paraffin-embedded human brain, using FRS2 Antibody. The picture on the right is blocked with the phospho peptide.

  • Western blot analysis of lysates from COS7 cells , using FRS2 Antibody. The lane on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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FRS2 (phospho Tyr436) Polyclonal Antibody | EnoGene Biotech Co. Ltd