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RARα (phospho Ser77) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60803

  • Amount:

    100ul

  • Swiss-Prot No.:

    P10276/P11416

  • Molecular Weight:

    50771，Observed Band : 45kd

  • Applications:

    WB,IHC-p,IF(paraffin section),ELISA

  • Reactivity:

    Human,Mouse,Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogen.

  • Immunogen:

    Phosphopeptide (Phospho-left) and NonPhosphopeptide (Phospho-right), using Retinoic Acid Receptoralpha (Phospho-Ser77) Antibody

  • Specificity/Sensitivity:

    Phospho-RARα (S77) Polyclonal Antibody detects endogenous levels of RARα
    protein only when phosphorylated at S77.

  • Storage/Stability:

    -20°C/1 year

  • Source:

    Rabbit

  • Gene Name:

    RARA

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA:
    1/5000. Not yet tested in other applications.

  • Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for

  • Background:

    retinoic acid receptor alpha(RARA) Homo sapiens This gene represents a
    nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha,
    regulates transcription in a ligand-dependent manner. This gene has been
    implicated in regulation of development, differentiation, apoptosis, granulopoeisis,
    and transcription of clock genes. Translocations between this locus and several
    other loci have been associated with acute promyelocytic leukemia. Alternatively
    spliced transcript variants have been found for this locus.[provided by RefSeq,
    Sep 2010]

  • Gene ID:

    5914/19401

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

  • Function:

    disease:Chromosomal aberrations involving RARA may be a cause of acute
    promyelocytic leukemia (APL) [MIM:612376]. Translocation t(11;17)(q32;q21)
    with ZBTB16/PLZF; translocation t(15;17)(q21;q21) with PML; translocation
    t(5;17)(q32;q11) with NPM.,domain:Composed of three domains: a modulating Nterminal domain, a DNA-binding domain and a C-terminal steroid-binding
    domain.,function:This is a receptor for retinoic acid. This metabolite has profound
    effects on vertebrate development. Retinoic acid is a morphogen and is a
    powerful teratogen. This receptor controls cell function by directly regulating gene

  • Expression:

    .,online information:Retinoic acid receptor entry,PTM:Phosphorylated.Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is
    crucial for transcriptional activity.,similarity:Belongs to the nuclear hormone
    receptor family.,similarity:Belongs to the nuclear

  • Immunohistochemistry analysis of paraffin-embedded human
    breast carcinoma, using Retinoic Acid Receptor alpha (Phospho Ser77) Antibody. The picture on the right is blocked with the
    phospho peptide.

  • Western blot analysis of lysates from Jurkat cells treated with
    PMA 125ng/ml 30' and Jurkat cells treated with insulin 0.01U/ml
    15', using Retinoic Acid Receptor alpha (Phospho-Ser77)
    Antibody. The lane on the right is blocked with the phospho
    peptide.

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Catalog Number

  • Amount:100ul
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RARα (phospho Ser77) Polyclonal Antibody | EnoGene Biotech Co. Ltd