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Trk C (phospho Tyr516) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60800

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Trk C around the phosphorylation site of Tyr516. AA range:482-531

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of HELA cells using Phospho-Trk C (Y516) Polyclonal Antibody

  • Gene Name:

    NTRK3

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Background:

    neurotrophic receptor tyrosine kinase 3(NTRK3) Homo sapiens This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],

  • Protein Name:

    NT-3 growth factor receptor

  • Human Gene Id:

    4916

  • Human Swiss Prot No:

    Q16288

  • Mouse Gene Id:

    18213

  • Mouse Swiss Prot No:

    Q6VNS1

  • Rat Gene Id:

    29613

  • Rat Swiss Prot No:

    Q03351

  • Specificity:

    Phospho-Trk C (Y516) Polyclonal Antibody detects endogenous levels of Trk C protein only when phosphorylated at Y516.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    NTRK3; TRKC; NT-3 growth factor receptor; GP145-TrkC; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase

  • MolecularWeight(Da):

    94428

  • Observed Band(KD):

    160

  • Function:

    alternative products:Additional isoforms seem to exist,catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.,PTM:Ligand-mediated auto-phosphorylation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 2 LRR (leucine-rich) repeats.,subunit:Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220.,tissue specificity:Widely expressed but mainly i

  • Subcellular Location:

    cytoplasm,integral component of plasma membrane,membrane,integral component of membrane,receptor complex,

  • Expression:

    Brain,Fetal brain,

  • Immunohistochemistry analysis of paraffin-embedded human brain, using Trk C (Phospho-Tyr516) Antibody. The picture on the right is blocked with the phospho peptide.

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  • Amount:100ul
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