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Axl (phospho Tyr691) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60779

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human AXL around the phosphorylation site of Tyr691. AA range:657-706

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of HuvEc cells using Phospho-Axl (Y691) Polyclonal Antibody diluted at 1:500

  • Gene Name:

    AXL

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Background:

    AXL receptor tyrosine kinase(AXL) Homo sapiens The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],

  • Protein Name:

    Tyrosine-protein kinase receptor UFO

  • Human Gene Id:

    558

  • Human Swiss Prot No:

    P30530

  • Mouse Gene Id:

    26362

  • Mouse Swiss Prot No:

    Q00993

  • Specificity:

    Phospho-Axl (Y691) Polyclonal Antibody detects endogenous levels of Axl protein only when phosphorylated at Y691.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    AXL; UFO; Tyrosine-protein kinase receptor UFO; AXL oncogene

  • MolecularWeight(Da):

    97437

  • Observed Band(KD):

    110 97

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia.,function:May function as a signal transducer between specific cell types of mesodermal origin. In case of filovirus infection, seems to function as a cell entry factor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Heterodimer and heterotetramer with GAS6.,tissue specificity:Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.,

  • Subcellular Location:

    extracellular space,intracellular,plasma membrane,integral component of plasma membrane,cell surface,integral component of membrane,host cell surface,extracellular exosome,

  • Expression:

    Colon tumor,Fibroblast,

  • Immunohistochemistry analysis of paraffin-embedded human brain, using AXL (Phospho-Tyr691) Antibody. The picture on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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Axl (phospho Tyr691) Polyclonal Antibody | EnoGene Biotech Co. Ltd