You are here: EnoGene Home > Products > Cell Signal Transduction Research Antibodies > Rb (phospho Ser608) Polyclonal Antibody

Rb (phospho Ser608) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60774

  • Amount:

    100ul

  • Swiss-Prot No.:

    P06400/P13405/ P33568

  • Molecular Weight:

    106159，Observed Band : 110kd

  • Applications:

    WB,IHC-p,IF(paraffin section),ELISA

  • Reactivity:

    Human,Mouse,Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogen.

  • Immunogen:

    Phosphopeptide (Phospho-left) and NonPhosphopeptide (Phospho-right), using Retinoblastoma(Phospho-Ser608) Antibody

  • Specificity/Sensitivity:

    Phospho-Rb (S608) Polyclonal Antibody detects endogenous levels of Rb
    protein only when phosphorylated at S608.

  • Storage/Stability:

    -20°C/1 year

  • Source:

    Rabbit

  • Gene Name:

    RB1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA:
    1/40000. Not yet tested in other applications

  • Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for

  • Background:

    rRB transcriptional corepressor 1(RB1) Homo sapiens The protein encoded by
    this gene is a negative regulator of the cell cycle and was the first tumor
    suppressor gene found. The encoded protein also stabilizes constitutive
    heterochromatin to maintain the overall chromatin structure. The active,
    hypophosphorylated form of the protein binds transcription factor E2F1. Defects
    in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer,
    and osteogenic sarcoma. [provided by RefSeq, Jul 2008],

  • Gene ID:

    5925/19645/24708

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

  • Function:

    disease:Defects in RB1 are a cause of bladder cancer
    [MIM:109800].,disease:Defects in RB1 are a cause of osteogenic sarcoma
    [MIM:259500].,disease:Defects in RB1 are the cause of childhood cancer
    retinoblastoma (RB) [MIM:180200]. RB is a congenital malignant tumor that
    arises from the nuclear layers of the retina. It occurs in about 1:20'000 live births
    and represents about 2% of childhood malignancies. It is bilateral in about 30% of
    cases. Although most RB appear sporadically, about 20% are transmitted as an
    autosomal dominant trait with incomplete penetrance. The diagnosis is usually
    made before the age of 2 years when strabismus or a gray to yellow reflex from
    pupil ("cat eye") is investigated.,function:Key regulator of entry into cell division
    that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target
    genes. The underphosphorylated, active form of RB1 interacts

  • Immunohistochemistry analysis of paraffin-embedded human
    brain, using Retinoblastoma (Phospho-Ser608) Antibody. The
    picture on the right is blocked with the phospho peptide.

  • Western blot analysis of lysates from Jurkat cells treated with
    PMA 125ng/ml 30', using Retinoblastoma (Phospho-Ser608)
    Antibody. The lane on the right is blocked with the phospho
    peptide.

Add to Cart

Related Products

PTEN (Phospho-Ser380) Antibody
PTEN (Phospho-Ser380) Antibody Datasheet  

  • Catalog Number:

    E011009-1

  • Amount:

    50μg/50μl

  • Reactivity:

    Human, Mouse, Rat

  • Applications:

    IHC: 1:50~1:100

  • Swiss-Prot No.:

    P60484

  • Price:

    145$
  • Add to Cart
PTEN (Phospho-Ser380) Antibody
PTEN (Phospho-Ser380) Antibody Datasheet  

  • Catalog Number:

    E011009-2

  • Amount:

    100μg/100μl

  • Reactivity:

    Human, Mouse, Rat

  • Applications:

    IHC: 1:50~1:100

  • Swiss-Prot No.:

    P60484

  • Price:

    225$
  • Add to Cart
NFκB-p65 (Phospho-Ser468) Antibody
NFκB-p65 (Phospho-Ser468) Antibody Datasheet  

  • Catalog Number:

    E011013-1

  • Amount:

    50μg/50μl

  • Reactivity:

    Human, Mouse, Rat

  • Applications:

    WB: 1:500~1:1000 IF:1:100~1:200

  • Swiss-Prot No.:

    Q04206

  • Price:

    145$
  • Add to Cart
NFκB-p65 (Phospho-Ser468) Antibody
NFκB-p65 (Phospho-Ser468) Antibody Datasheet  

  • Catalog Number:

    E011013-2

  • Amount:

    100μg/100μl

  • Reactivity:

    Human, Mouse, Rat

  • Applications:

    WB: 1:500~1:1000 IF:1:100~1:200

  • Swiss-Prot No.:

    Q04206

  • Price:

    225$
  • Add to Cart
Rel (Phospho-Ser503) Antibody
Rel (Phospho-Ser503) Antibody Datasheet  

  • Catalog Number:

    E011020-1

  • Amount:

    50μg/50μl

  • Reactivity:

    Human

  • Applications:

    IF:1:100~1:200

  • Swiss-Prot No.:

    Q04864

  • Price:

    145$
  • Add to Cart

Catalog Number

  • Amount:100ul
  • Price:225$

Add to Cart

AbPromise

Contact us

Rb (phospho Ser608) Polyclonal Antibody | EnoGene Biotech Co. Ltd