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ERK 3 (phospho Ser189) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60738

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human ERK3 around the phosphorylation site of Ser189. AA range:155-204

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    MAPK6

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Western blot analysis of lysates from mouse brain, using ERK3 (Phospho-Ser189) Antibody. The lane on the right is blocked with the phospho peptide.

  • Background:

    mitogen-activated protein kinase 6(MAPK6) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Mitogen-activated protein kinase 6

  • Human Gene Id:

    5597

  • Human Swiss Prot No:

    Q16659

  • Specificity:

    Phospho-ERK 3 (S189) Polyclonal Antibody detects endogenous levels of ERK 3 protein only when phosphorylated at S189.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MAPK6; ERK3; PRKM6; Mitogen-activated protein kinase 6; MAP kinase 6; MAPK 6; Extracellular signal-regulated kinase 3; ERK-3; MAP kinase isoform p97; p97-MAPK

  • MolecularWeight(Da):

    82681

  • Observed Band(KD):

    90

  • Function:

    catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation.,function:Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle.,PTM:Dually phosphorylated on Thr-626 and Tyr-628, which activates the enzyme.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.,

  • Subcellular Location:

    nucleus,nucleoplasm,cytoplasm,cytosol,septin cytoskeleton,protein complex,

  • Expression:

    Fetal skeletal muscle,Oesophageal carcinoma,Oral cancer,Placenta,Sm

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using ERK3 (Phospho-Ser189) Antibody. The picture on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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ERK 3 (phospho Ser189) Polyclonal Antibody | EnoGene Biotech Co. Ltd