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CD71/TfR (phospho Ser24) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60729

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human CD71/TfR around the phosphorylation site of Ser24. AA range:15-64

  • Source:

    Polyclonal, Rabbit

  • Immunohistochemistry analysis of paraffin-embedded human brain, using CD71/TfR (Phospho-Ser24) Antibody. The picture on the right is blocked with the phospho peptide.

  • Gene Name:

    TFRC

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Background:

    transferrin receptor(TFRC) Homo sapiens This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015],

  • Protein Name:

    Transferrin receptor protein 1

  • Human Gene Id:

    4155

  • Human Swiss Prot No:

    P02786

  • Mouse Gene Id:

    22042

  • Mouse Swiss Prot No:

    Q62351

  • Specificity:

    Phospho-CD71 (S24) Polyclonal Antibody detects endogenous levels of CD71 protein only when phosphorylated at S24.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    TFRC; Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD antigen CD71

  • MolecularWeight(Da):

    84871

  • Observed Band(KD):

    89

  • Function:

    function:Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.,induction:Regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.,miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use t

  • Subcellular Location:

    extracellular region,extracellular space,endosome,plasma membrane,integral component of plasma membrane,clathrin-coated pit,external side of plasma membrane,cell surface,membrane,integral component of membrane,cytoplasmic, membrane-bounded

  • Expression:

    Brain,Epithelium,Erythroleukemia,Eye,Human endometrium carcinoma cell line,Liver,Pl

  • Western blot analysis of lysates from 293 cells treated with PMA 125ng/ml 30' , using CD71/TfR (Phospho-Ser24) Antibody. The lane on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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CD71/TfR (phospho Ser24) Polyclonal Antibody | EnoGene Biotech Co. Ltd