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Ah Receptor (phospho Ser36) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60713

  • Amount:

    100ul

  • Molecular Weight:

    96147/76239Da

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human AhR around the phosphorylation site of Ser36. AA range:2-51

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of HepG2 cells using Phospho-Ah Receptor (S36) Polyclonal Antibody

  • Gene Name:

    AHR

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Protein Name:

    Aryl hydrocarbon receptor

  • Human Gene Id:

    196/57491

  • Human Swiss Prot No:

     

  • Specificity:

    Phospho-Ah Receptor (S36) Polyclonal Antibody detects endogenous levels of Ah Receptor protein only when phosphorylated at S36.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    AHR; BHLHE76; Aryl hydrocarbon receptor; Ah receptor; AhR; Class E basic helix-loop-helix protein 76; bHLHe76; AHRR; BHLHE77; KIAA1234; Aryl hydrocarbon receptor repressor; AhR repressor; AhRR; Class E basic helix-loop-helix protein 77; bHL

  • Observed Band(KD):

    90

  • Background:

    aryl hydrocarbon receptor(AHR) Homo sapiens The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015],

  • Function:

    function:Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.,induction:Induced or repressed by TGF-beta and dioxin in a cell-type specific fashion. Repressed by cAMP, retinoic acid, and TPA.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subcellular location:Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.,subunit:Binds MYBBP1A (By similarity)

  • Subcellular Location:

    nucleus,nucleoplasm,transcription factor complex,cytoplasm,aryl hydrocarbon receptor complex,cytosolic aryl hydrocarbon receptor complex,nuclear aryl hydrocarbon receptor complex,

  • Expression:

    Liver,Placenta,

  • Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using AhR (Phospho-Ser36) Antibody

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Catalog Number

  • Amount:100ul
  • Price:225$

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