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Pin1 (phospho Ser16) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60702

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Pin1 around the phosphorylation site of Ser16. AA range:1-50

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    PIN1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using Pin1 (Phospho-Ser16) Antibody

  • Background:

    peptidylprolyl cis/trans isomerase, NIMA-interacting 1(PIN1) Homo sapiens Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011],

  • Protein Name:

    Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

  • Human Gene Id:

    5300

  • Human Swiss Prot No:

    Q13526

  • Mouse Gene Id:

    23988

  • Mouse Swiss Prot No:

    Q9QUR7

  • Specificity:

    Phospho-Pin1 (S16) Polyclonal Antibody detects endogenous levels of Pin1 protein only when phosphorylated at S16.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    PIN1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis-trans isomerase Pin1; PPIase Pin1; Rotamase Pin1

  • MolecularWeight(Da):

    18243

  • Observed Band(KD):

    18

  • Function:

    catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,domain:The WW domain is required for the interaction with STIL and MPHOSPH1.,function:Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzing pSer/Thr-Pro cis/trans isomerizations.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 PpiC domain.,similarity:Contains 1 WW domain.,subunit:Interacts with STIL (By similarity). Interacts with MPHOSPH1.,

  • Subcellular Location:

    nucleus,nucleoplasm,mitochondrion,cytosol,nuclear speck,midbody,neuron projection,

  • Expression:

    Lung,Testis,

  • Immunohistochemistry analysis of paraffin-embedded human heart, using Pin1 (Phospho-Ser16) Antibody. The picture on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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Pin1 (phospho Ser16) Polyclonal Antibody | EnoGene Biotech Co. Ltd