Product Information
Molecular Weight58524Da
Protein NameTyrosine 3-monooxygenase
Rat Gene Id25085
Rat Swiss Prot NoP04177
SpecificityPhospho-TH (S8) Polyclonal Antibody detects endogenous levels of TH protein only when phosphorylated at S8.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTH; TYH; Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH
Observed Band(KD)62
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from mouse Tyrosine Hydroxylase around the phosphorylation site of Ser8. AA range:2-51
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
BackgroundThe tyrosine hydroxylase encoded by TH is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.