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Raf-1 (phospho Tyr341) Polyclonal Antibody
Datasheet
Catalog Number:
E20-60670Amount:
100ulSwiss-Prot No.:
P04049/ Q99N57/ P11345Molecular Weight:
73052，Observed Band : 73kdApplications:
WB,IHC-p,IF(paraffin section),ELISAReactivity:
Human,Mouse,RatPurification:
The antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogenImmunogen:
Phosphopeptide (Phospho-left) and Non Phosphopeptide (Phospho-right), using C-RAF (Phospho-Tyr341) AntibodySpecificity/Sensitivity:
Phospho-Raf-1 (Y341) Polyclonal Antibody detects endogenous levels of Raf-1
protein only when phosphorylated at Y341.Storage/Stability:
-20°C/1 yearSource:
RabbitGene Name:
RAF1Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA:
1/10000. Not yet tested in other applications.
- Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for
Background:
Raf-1 proto-oncogene, serine/threonine kinase(RAF1) Homo sapiens This gene
is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP
kinase kinase kinase (MAP3K), which functions downstream of the Ras family of
membrane associated GTPases to which it binds directly. Once activated, the
cellular RAF1 protein can phosphorylate to activate the dual specificity protein
kinases MEK1 and MEK2, which in turn phosphorylate to activate the
serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are
pleiotropic effectors of cell physiology and play an important role in the control of
gene expression involved in the cell division cycle, apoptosis, cell differentiation
and cell migration. Mutations in this gene are associated with Noonan syndrome 5
and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
1 in 1000-2500 live births.,function:Involved in the transductiGene ID:
5894/110157/ 24703Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Immunohistochemistry analysis of paraffin-embedded human
pancreas, using C-RAF (Phospho-Tyr341) Antibody. The picture
on the right is blocked with the phospho peptide. 
- Western blot analysis of lysates from Jurkat cells treated with
Paclitaxel 1uM 24h, using C-RAF (Phospho-Tyr341) Antibody.
The lane on the right is blocked with the phospho peptide.
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