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c-Kit (phospho Tyr703) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60658

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human KIT around the phosphorylation site of Tyr703. AA range:671-720

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    KIT

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using KIT (Phospho-Tyr703) Antibody. The picture on the right is blocked with the phospho peptide.

  • Background:

    KIT proto-oncogene receptor tyrosine kinase(KIT) Homo sapiens This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Mast/stem cell growth factor receptor Kit

  • Human Gene Id:

    3815

  • Human Swiss Prot No:

    P10721

  • Mouse Gene Id:

    16590

  • Mouse Swiss Prot No:

    P05532

  • Specificity:

    Phospho-c-Kit (Y703) Polyclonal Antibody detects endogenous levels of c-Kit protein only when phosphorylated at Y703.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    KIT; SCFR; Mast/stem cell growth factor receptor Kit; SCFR; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD antigen CD117

  • MolecularWeight(Da):

    109865

  • Observed Band(KD):

    145

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764].,disease:Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes.,disease:Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).,function:This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).,online information:CD117 entry,similarity:Belongs to the protein kinas

  • Subcellular Location:

    acrosomal vesicle,extracellular space,plasma membrane,cell-cell junction,external side of plasma membrane,cytoplasmic side of plasma membrane,membrane,integral component of membrane,mast cell granule,

  • Expression:

    Bone marrow,Brain,Fetal brain,Gastrointestinal stromal tumo

  • Western blot analysis of lysates from HepG2 cells treated with EGF 200ng/ml 30', using KIT (Phospho-Tyr703) Antibody. The lane on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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