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Arrestin-β-1 (phospho Ser412) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60642

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Arrestin 1 around the phosphorylation site of Ser412. AA range:369-418

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    ARRB1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

  • Background:

    arrestin beta 1(ARRB1) Homo sapiens Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011],

  • Protein Name:

    Beta-arrestin-1

  • Human Gene Id:

    408

  • Human Swiss Prot No:

    P49407

  • Mouse Swiss Prot No:

    Q8BWG8

  • Specificity:

    Phospho-Arrestin-β-1 (S412) Polyclonal Antibody detects endogenous levels of Arrestin-β-1 protein only when phosphorylated at S412.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ARRB1; ARR1; Beta-arrestin-1; Arrestin beta-1

  • MolecularWeight(Da):

    47066

  • Observed Band(KD):

    47

  • Function:

    function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family.,

  • Subcellular Location:

    Golgi membrane,chromatin,nucleus,nucleoplasm,cytoplasm,lysosomal membrane,cytosol,heterotrimeric G-protein complex,plasma membrane,clathrin-coated pit,postsynaptic density,basolateral plasma membrane,cytoplasmic vesicle membr

  • Expression:

    Brain,Peripheral blood,Uterus,

  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Arrestin 1 (Phospho-Ser412) Antibody. The picture on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
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Arrestin-β-1 (phospho Ser412) Polyclonal Antibody | EnoGene Biotech Co. Ltd