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IL-3Rβ (phospho Tyr593) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60639

  • Amount:

    100ul

  • Molecular Weight:

    97336Da

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human IL-3R beta around the phosphorylation site of Tyr593. AA range:559-608

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    CSF2RB

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

  • Protein Name:

    Cytokine receptor common subunit beta

  • Human Gene Id:

    1439

  • Human Swiss Prot No:

    P32927

  • Mouse Gene Id:

    12983

  • Mouse Swiss Prot No:

    P26955

  • Specificity:

    Phospho-IL-3Rβ (Y593) Polyclonal Antibody detects endogenous levels of IL-3Rβ protein only when phosphorylated at Y593.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    CSF2RB; IL3RB; IL5RB; Cytokine receptor common subunit beta; CDw131; GM-CSF/IL-3/IL-5 receptor common beta subunit; CD antigen CD131

  • Observed Band(KD):

    44

  • Background:

    colony stimulating factor 2 receptor beta common subunit(CSF2RB) Homo sapiens The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008],

  • Function:

    disease:Defects in CSF2RB are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.,similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subunit:Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.,

  • Subcellular Location:

    intracellular,plasma membrane,integral component of plasma membrane,integral component of membrane,granulocyte macrophage colony-stimulating factor receptor complex,

  • Expression:

    Placenta,

  • Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using IL-3R beta (Phospho-Tyr593) Antibody

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