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PLC γ2 (phospho Tyr753) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60608

  • Amount:

    100ul

  • Molecular Weight:

    147937 Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISAReaGene Name:PLCG2

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human PLCG2 around the phosphorylation site of Tyr753. AA range:721-770

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Phospho-PLC γ2 Polyclonal Antibody

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Background:

    The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014],

  • Protein Name:

    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

  • Human Gene Id:

    5336

  • Human Swiss Prot No:

    P16885

  • Mouse Gene Id:

    234779

  • Mouse Swiss Prot No:

    Q8CIH5

  • Rat Gene Id:

    29337

  • Rat Swiss Prot No:

    P24135

  • Specificity:

    Phospho-PLC γ2 (Y753) Polyclonal Antibody detects endogenous levels of PLC γ2 protein only when phosphorylated at Y753.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    PLCG2; 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2

  • Observed Band(KD):

    148

  • Function:

    catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.,PTM:Phosphorylated on tyrosine residues; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Increases phospholipase activity.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,

  • Subcellular Location:

    intracellular,cytosol,plasma membrane,extracellular exosome,

  • Expression:

    Lymph,Lymphoblast,Spleen,T-cell,ctivity:Human;Mouse;Rat

  • Western blot analysis of lysates from HepG2 cells treated with Na3VO4 0.3mM 40', using PLCG2 Antibody. The lane on the right is blocked with the phospho peptide.

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Catalog Number

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PLC γ2 (phospho Tyr753) Polyclonal Antibody | EnoGene Biotech Co. Ltd