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PLC β3 (phospho Ser1105) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60606

  • Amount:

    100ul

  • Molecular Weight:

    138799 Da

  • Applications:

    WB;IHC-p;IF(paraffin section);ELISA

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human PLCB3 around the phosphorylation site of Ser1105. AA range:1071-1120

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Phospho-PLC β3 Polyclonal Antibody diluted at 1:1000

  • Gene Name:

    PLCB3

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Background:

    This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],

  • Protein Name:

    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

  • Human Gene Id:

    5331

  • Human Swiss Prot No:

    Q01970

  • Mouse Swiss Prot No:

    P51432

  • Rat Swiss Prot No:

    Q99JE6

  • Specificity:

    Phospho-PLC β3 (S1105) Polyclonal Antibody detects endogenous levels of PLC β3 protein only when phosphorylated at S1105.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    PLCB3; 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase beta-3; Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3; PLC-beta-3

  • Observed Band(KD):

    160

  • Function:

    catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,subunit:Interacts with SHANK2 (By similarity). Interacts with LPAR2.,

  • Subcellular Location:

    Cytoplasm . Membrane . Nucleus . And particulate fractions. .

  • Expression:

    Epithelium,Uterus,

  • Western blot analysis of lysates from A431 cells, using PLCB3 Antibody. The lane on the right is blocked with the phospho peptide.

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