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CD45 (phospho Ser1007) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60543

  • Amount:

    100ul

  • Swiss-Prot No.:

    P08575/ P06800/ P04157

  • Molecular Weight:

    147254，Observed Band : 150kd

  • Applications:

    WB,IF/ICC,ELISA

  • Reactivity:

    Human,Mouse,Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human
    CD45 around the phosphorylation site of Ser1007. AA range:981-1030

  • Specificity/Sensitivity:

    Phospho-CD45 (S1007) Polyclonal Antibody detects endogenous levels of
    CD45 protein only when phosphorylated at S1007.

  • Storage/Stability:

    -20°C/1 year

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    PTPRC

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA:
    1/5000. Not yet tested in other applications

  • Immunofluorescence analysis of HeLa cells, using CD45 (Phospho-Ser1007) Antibody. The picture on the right is blocked with the phospho peptide.

  • Background:

    protein tyrosine phosphatase, receptor type C(PTPRC) Homo sapiens The
    protein encoded by this gene is a member of the protein tyrosine phosphatase
    (PTP) family. PTPs are known to be signaling molecules that regulate a variety of
    cellular processes including cell growth, differentiation, mitosis, and oncogenic
    transformation. This PTP contains an extracellular domain, a single
    transmembrane segment and two tandem intracytoplasmic catalytic domains, and
    thus is classified as a receptor type PTP. This PTP has been shown to be an
    essential regulator of T- and B-cell antigen receptor signaling. It functions through
    either direct interaction with components of the antigen receptor complexes, or by
    activating various Src family kinases required for the antigen receptor signaling.
    This PTP also suppresses JAK kinases, and thus functions as a regulator of
    cytokine receptor signaling. Alternatively spliced transcripts variants of this gene,
    which enc

  • Gene ID:

    5788/24699

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

  • Function:

    alternative products:At least 8 isoforms are produced,catalytic activity:Protein
    tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,disease:Defects in
    PTPRC are a cause of severe combined immunodeficiency autosomal recessive
    T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+)SCID)
    [MIM:608971]. SCID refers to a genetically and clinically heterogeneous group of
    rare congenital disorders characterized by impairment of both humoral and cellmediated immunity, leukopenia, and low or absent antibody levels. Patients with
    SCID present in infancy with recurrent, persistent infections by opportunistic
    organisms. The common characteristic of all types of SCID is absence of T-cellmediated cellular immunity due to a defect in T-cell development.,disease:Genetic
    variations in PTPRC are involved in multiple sclerosis susceptibility (MS)
    [MIM:126200]. MS is a neurodegenerative dis

  • Western blot analysis of lysates from HeLa cells treated with TNF 20ng/ml 15', using CD45 (Phospho-Ser1007) Antibody. The lane on the right is blocked with the phospho peptide

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CD45 (phospho Ser1007) Polyclonal Antibody | EnoGene Biotech Co. Ltd