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Rb (phospho Ser811) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60539

  • Amount:

    100ul

  • Swiss-Prot No.:

    P06400/P13405/ P33568

  • Molecular Weight:

    106159，Observed Band : 106kd

  • Reactivity:

    Human,Mouse,Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogen.

  • Immunogen:

    Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using Retinoblastoma(Phospho-Ser811) Antibody

  • Specificity/Sensitivity:

    Phospho-Rb (S811) Polyclonal Antibody detects endogenous levels of Rb
    protein only when phosphorylated at S811.

  • Storage/Stability:

    -20°C/1 year

  • Source:

    Rabbit

  • Gene Name:

    RB1

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300.
    Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other

  • Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for

  • Background:

    RB transcriptional corepressor 1(RB1) Homo sapiens The protein encoded by
    this gene is a negative regulator of the cell cycle and was the first tumor
    suppressor gene found. The encoded protein also stabilizes constitutive
    heterochromatin to maintain the overall chromatin structure. The active,
    hypophosphorylated form of the protein binds transcription factor E2F1. Defects
    in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer,
    and osteogenic sarcoma. [provided by RefSeq, Jul 2008],

  • Gene ID:

    5925/19645/24708

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

  • Function:

    disease:Defects in RB1 are a cause of bladder cancer
    [MIM:109800].,disease:Defects in RB1 are a cause of osteogenic sarcoma
    [MIM:259500].,disease:Defects in RB1 are the cause of childhood cancer
    retinoblastoma (RB) [MIM:180200]. RB is a congenital malignant tumor that
    arises from the nuclear layers of the retina. It occurs in about 1:20'000 live births
    and represents about 2% of childhood malignancies. It is bilateral in about 30% of
    cases. Although most RB appear sporadically, about 20% are transmitted as an
    autosomal dominant trait with incomplete penetrance. The diagnosis is usually
    made before the age of 2 years when strabismus or a gray to yellow reflex from
    pupil ("cat eye") is investigated.,function:Key regulator of entry into cell division
    that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target
    genes. The underphosphorylated, active form of RB1 interacts

  • Immunofluorescence analysis of HUVEC cells, using
    Retinoblastoma (Phospho-Ser811) Antibody. The picture on the
    right is blocked with the phospho peptide.

  • Western blot analysis of lysates from K562 cells, using
    Retinoblastoma (Phospho-Ser811) Antibody. The lane on the
    right is blocked with the phospho peptide

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Catalog Number

  • Amount:100ul
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Rb (phospho Ser811) Polyclonal Antibody | EnoGene Biotech Co. Ltd