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Integrin β3 (phospho Tyr785) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60524

  • Amount:

    100ul

  • Molecular Weight:

    87214Da

  • Applications:

    IF/ICC;ELISA;IHC-p

  • Reactivity:

    Human;Mouse;Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Integrin beta3 around the phosphorylation site of Tyr785. AA range:739-788

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of various cells using Phospho-Integrin β3 (Y785) Polyclonal Antibody diluted at 1:500

  • Gene Name:

    ITGB3

  • Dilution:

    IF/ICC 1:50-300; ELISA 1:2000-20000; IHC-p 1:50-200

  • Background:

    The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Integrin beta-3

  • Human Gene Id:

    3690

  • Human Swiss Prot No:

    P05106

  • Mouse Gene Id:

    16416

  • Mouse Swiss Prot No:

    O54890

  • Specificity:

    Phospho-Integrin β3 (Y785) Polyclonal Antibody detects endogenous levels of Integrin β3 protein only when phosphorylated at Y785.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ITGB3; GP3A; Integrin beta-3; Platelet membrane glycoprotein IIIa; GPIIIa; CD antigen CD61

  • Observed Band(KD):

    87

  • Function:

    disease:Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. Its inheritance is autosomal recessive. It is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT variants have normal or near normal (60-100%) expression of dysfunctional receptors.,function:Int

  • Subcellular Location:

    Cell membrane ; Single-pass type I membrane protein . Cell projection, lamellipodium membrane . Cell junction, focal adhesion . Cell junction, synapse, postsynaptic cell membrane ; Single-pass type I membrane protein . Cell junction, synapse .

  • Expression:

    Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

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Integrin β3 (phospho Tyr785) Polyclonal Antibody | EnoGene Biotech Co. Ltd