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EphA4 (phospho Tyr596) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60507

  • Amount:

    100ul

  • Molecular Weight:

    109860(DA) Observed Band(KD)110

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    Synthesized phospho-peptide around the phosphorylation site of human EphA4 (phospho Tyr596)

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of JK cells using Phospho-EphA4 (Y596) Polyclonal Antibody

  • Gene Name:

    EPHA4

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Ephrin type-A receptor 4

  • Human Gene Id:

    2043

  • Human Swiss Prot No:

    P54764

  • Mouse Gene Id:

    13838

  • Mouse Swiss Prot No:

    Q03137

  • Specificity:

    Phospho-EphA4 (Y596) Polyclonal Antibody detects endogenous levels of EphA4 protein only when phosphorylated at Y596.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    EPHA4; HEK8; SEK; TYRO1; Ephrin type-A receptor 4; EPH-like kinase 8; EK8; hEK8; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK

  • Background:

    EPH receptor A4(EPHA4) Homo sapiens This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:The protein kinase domain mediates interaction with NGEF/ephexin-1.,function:Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in a signal transduction process involved in hindbrain pattern formation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with the src family kinase, p59-Fyn, through the major phosphorylation site at position Tyr-602. Interacts with NGEF/ephexin-1.,tissue specificity:Ubiquitous.

  • Subcellular Location:

    cytoplasm,mitochondrial outer membrane,endoplasmic reticulum,Golgi apparatus,plasma membrane,integral component of plasma membrane,cell surface,postsynaptic density,integral component of membrane,cell junction,filopodium,axon,

  • Expression:

    Brain,Fetal brain,Lung,

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Catalog Number

  • Amount:100ul
  • Price:225$

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