TPH2 (phospho Ser19) Polyclonal Antibody

Name: TPH2 (phospho Ser19) Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-60501
Price: 225 USD
Availability: InStock

E20-60501Cite ID: EN0049427Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight56057Da

Protein NameTryptophan 5-hydroxylase 2

Human Gene Id121278

Human Swiss Prot NoQ8IWU9

Mouse Gene Id216343

Mouse Swiss Prot NoQ8CGV2

Rat Gene Id317675

Rat Swiss Prot NoQ8CGU9

SpecificityPhospho-TPH2 (S19) Polyclonal Antibody detects endogenous levels of TPH2 protein only when phosphorylated at S19.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameTPH2; NTPH; Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2

Observed Band(KD)56

Functioncatalytic activity:L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,disease:Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].,pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,similarity:Contains 1 ACT domain.,tissue specificity:Brain specific.,

Subcellular Locationcytosol,neuron projection,

ExpressionAmygdala,PCR rescued clones,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenSynthesized phospho-peptide around the phosphorylation site of human TPH2 (phospho Ser19)

Gene NameTPH2

DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Backgroundtryptophan hydroxylase 2(TPH2) Homo sapiens This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-60501-Conjugate. Price: $485 / Size: 100μl.

E20-60501-FITC$485 / 100μlE20-60501-Biotin$485 / 100μlE20-60501-HRP$485 / 100μlE20-60501-AP$485 / 100μlE20-60501-AF350$485 / 100μlE20-60501-AF405M$485 / 100μlE20-60501-AF488$485 / 100μlE20-60501-AF514$485 / 100μlE20-60501-AF532$485 / 100μlE20-60501-AF555$485 / 100μlE20-60501-AF568$485 / 100μlE20-60501-AF405S$485 / 100μlE20-60501-AF405L$485 / 100μlE20-60501-AF546$485 / 100μlE20-60501-AF594$485 / 100μlE20-60501-AF610$485 / 100μlE20-60501-AF635$485 / 100μlE20-60501-AF647$485 / 100μlE20-60501-AF680$485 / 100μlE20-60501-AF700$485 / 100μlE20-60501-AF750$485 / 100μlE20-60501-AF790$485 / 100μlE20-60501-APC$485 / 100μlE20-60501-PE$485 / 100μlE20-60501-Cy3$485 / 100μlE20-60501-Cy5$485 / 100μlE20-60501-Cy5.5$485 / 100μlE20-60501-Cy7$485 / 100μlE20-60501-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.