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PC-PLD1 (phospho Thr147) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60487

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    Synthesized phospho-peptide around the phosphorylation site of human PC-PLD1 (phospho Thr147)

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    PLD1

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

  • Background:

    phospholipase D1(PLD1) Homo sapiens This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011],

  • Protein Name:

    Phospholipase D1

  • Human Gene Id:

    5337

  • Human Swiss Prot No:

    Q13393

  • Mouse Swiss Prot No:

    Q9Z280

  • Rat Gene Id:

    25096

  • Rat Swiss Prot No:

    P70496

  • Specificity:

    Phospho-PC-PLD1 (T147) Polyclonal Antibody detects endogenous levels of PC-PLD1 protein only when phosphorylated at T147.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    PLD1; Phospholipase D1; PLD 1; hPLD1; Choline phosphatase 1; Phosphatidylcholine-hydrolyzing phospholipase D1

  • MolecularWeight(Da):

    124184

  • Observed Band(KD):

    120

  • Function:

    catalytic activity:A phosphatidylcholine + H(2)O = choline + a phosphatidate.,enzyme regulation:Stimulated by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42. Inhibited by oleate.,function:Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic.,online information:Phospholipase D entry,similarity:Belongs to the phospholipase D family.,similarity:Contains 1 PH domain.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 PLD phosphodiesterase domains.,subunit:Interacts with PIP5K1A.,tissue specificity:Expressed abundant

  • Subcellular Location:

    Golgi membrane,lysosomal membrane,endosome,endoplasmic reticulum membrane,Golgi apparatus,membrane,apical plasma membrane,endocytic vesicle,late endosome membrane,perinuclear region of cytoplasm,

  • Expression:

    Aorta endothelial cell,Brain,Cervix carcinoma,Chondrocyte,Epithelium,Skeletal muscle,Testis,

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Catalog Number

  • Amount:100ul
  • Price:225$

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PC-PLD1 (phospho Thr147) Polyclonal Antibody | EnoGene Biotech Co. Ltd