Product Information
Molecular Weight165763Da
Protein NameNuclear factor of activated T-cells 5
Human Gene Id10725
Human Swiss Prot NoO94916
Mouse Swiss Prot NoQ9WV30
SpecificityPhospho-NFAT5 (S155) Polyclonal Antibody detects endogenous levels of NFAT5 protein only when phosphorylated at S155.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNFAT5; KIAA0827; TONEBP; Nuclear factor of activated T-cells 5; NF-AT5; T-cell transcription factor NFAT5; Tonicity-responsive enhancer-binding protein; TonE-binding protein; TonEBP
Observed Band(KD)200
Functionalternative products:Experimental confirmation may be lacking for some isoforms,function:Plays a role in the inducible expression of genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.,similarity:Contains 1 RHD (Rel-like) domain.,subunit:Does not bind with Fos and Jun transcription factors. But might be capable of forming stable dimers with DNA elements.,tissue specificity:Highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes. Also expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon.,
Subcellular Locationnucleus,nucleoplasm,cytoplasm,integral component of membrane,
ExpressionBrain,PCR rescued clones,
Backgroundnuclear factor of activated T-cells 5(NFAT5) Homo sapiens The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],