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Eps15 (phospho Tyr849) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60469

  • Amount:

    100ul

  • Molecular Weight:

    98656(DA) Observed Band(KD):100

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    Synthesized phospho-peptide around the phosphorylation site of human Eps15 (phospho Tyr849)

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of JK cells using Phospho-Eps15 (Y849) Polyclonal Antibody

  • Gene Name:

    EPS15

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Epidermal growth factor receptor substrate 15

  • Human Gene Id:

    2060

  • Human Swiss Prot No:

    P42566

  • Mouse Gene Id:

    13858

  • Mouse Swiss Prot No:

    P42567

  • Specificity:

    Phospho-Eps15 (Y849) Polyclonal Antibody detects endogenous levels of Eps15 protein only when phosphorylated at Y849.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    EPS15; AF1P; Epidermal growth factor receptor substrate 15; Protein Eps15; Protein AF-1p

  • Background:

    epidermal growth factor receptor pathway substrate 15(EPS15) Homo sapiens This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009],

  • Function:

    disease:A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with MLL/HRX. The result is a rogue activator protein.,domain:The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.,function:Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits.,PTM:Phosphorylation on Tyr-849 is involved in the internalization of EGFR. Not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis (By similarity). Phosphorylated on serine upon DNA damage, probably by ATM or ATR.,similarity:Contains 2 EF-hand dom

  • Subcellular Location:

    cytoplasm,cytosol,plasma membrane,clathrin-coated pit,cell-cell adherens junction,basal plasma membrane,membrane,aggresome,apical plasma membrane,AP-2 adaptor complex,early endosome membrane,intra

  • Expression:

    Amygdala,Epithelium,Melanoma,Platelet,Skin,Trachea,

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Catalog Number

  • Amount:100ul
  • Price:225$

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Eps15 (phospho Tyr849) Polyclonal Antibody | EnoGene Biotech Co. Ltd