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4.1R (phospho Tyr660) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60468

  • Amount:

    100ul

  • Molecular Weight:

    97017(DA) Observed Band(KD)60

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human EPB41 around the phosphorylation site of Tyr660/418. AA range:626-675

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of JK cells using Phospho-4.1R (Y660) Polyclonal Antibody

  • Gene Name:

    EPB41

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Protein Name:

    Protein 4.1

  • Human Gene Id:

    2035

  • Human Swiss Prot No:

    P11171

  • Mouse Gene Id:

    269587

  • Mouse Swiss Prot No:

    P48193

  • Specificity:

    Phospho-4.1R (Y660) Polyclonal Antibody detects endogenous levels of 4.1R protein only when phosphorylated at Y660.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    EPB41; E41P; Protein 4.1; P4.1; 4.1R; Band 4.1; EPB4.1

  • Background:

    erythrocyte membrane protein band 4.1(EPB41) Homo sapiens The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009],

  • Function:

    disease:Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.,disease:Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:611804]. EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.,function:Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.,PTM:O-glycosylated; contains N-acetylglucosamine side chains in the C-ter

  • Subcellular Location:

    nucleus,cytoplasm,cytoskeleton,plasma membrane,spectrin,spectrin-associated cytoskeleton,extrinsic component of membrane,cell junction,cortical cytoskeleton,protein complex,

  • Expression:

    Brain,PCR rescued clones,Reticulocyte,Spleen,

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Catalog Number

  • Amount:100ul
  • Price:225$

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4.1R (phospho Tyr660) Polyclonal Antibody | EnoGene Biotech Co. Ltd