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Cell Signal Transduction Research Antibodies
Claudin-7 (phospho Tyr210) Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight22390Da
Protein NameClaudin-7
Human Gene Id1366
Human Swiss Prot NoO95471
Mouse Gene Id53624
Mouse Swiss Prot NoQ9Z261
Rat Gene Id65132
Rat Swiss Prot NoQ9Z1L1
SpecificityPhospho-Claudin-7 (Y210) Polyclonal Antibody detects endogenous levels of Claudin-7 protein only when phosphorylated at Y210.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCLDN7; CEPTRL2; CPETRL2; Claudin-7; CLDN-7
Observed Band(KD)32
Functionfunction:Plays a major role in tight junction-specific obliteration of the intercellular space.,induction:By androgens.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,tissue specificity:Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.,
Subcellular Locationplasma membrane,bicellular tight junction,integral component of membrane,basolateral plasma membrane,apicolateral plasma membrane,lateral plasma membrane,
ExpressionColon,Colon adenocarcinoma,Mammary gland,Placenta,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Claudin 7 around the phosphorylation site of Tyr210. AA range:162-211
Gene NameCLDN7
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Backgroundclaudin 7(CLDN7) Homo sapiens This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-60466-Conjugate. Price: $485 / Size: 100μl.
E20-60466-FITC$485 / 100μlE20-60466-Biotin$485 / 100μlE20-60466-HRP$485 / 100μlE20-60466-AP$485 / 100μlE20-60466-AF350$485 / 100μlE20-60466-AF405M$485 / 100μlE20-60466-AF488$485 / 100μlE20-60466-AF514$485 / 100μlE20-60466-AF532$485 / 100μlE20-60466-AF555$485 / 100μlE20-60466-AF568$485 / 100μlE20-60466-AF405S$485 / 100μlE20-60466-AF405L$485 / 100μlE20-60466-AF546$485 / 100μlE20-60466-AF594$485 / 100μlE20-60466-AF610$485 / 100μlE20-60466-AF635$485 / 100μlE20-60466-AF647$485 / 100μlE20-60466-AF680$485 / 100μlE20-60466-AF700$485 / 100μlE20-60466-AF750$485 / 100μlE20-60466-AF790$485 / 100μlE20-60466-APC$485 / 100μlE20-60466-PE$485 / 100μlE20-60466-Cy3$485 / 100μlE20-60466-Cy5$485 / 100μlE20-60466-Cy5.5$485 / 100μlE20-60466-Cy7$485 / 100μlE20-60466-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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