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Cell Signal Transduction Research Antibodies
Claudin-3 (phospho Tyr219) Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight23319Da
Protein NameClaudin-3
Human Gene Id1365
Human Swiss Prot NoO15551
Mouse Swiss Prot NoQ9Z0G9
SpecificityPhospho-Claudin-3 (Y219) Polyclonal Antibody detects endogenous levels of Claudin-3 protein only when phosphorylated at Y219.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCLDN3; C7orf1; CPETR2; Claudin-3; Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; Rat ventral prostate.1 protein homolog; hRVP1
Observed Band(KD)28
Functiondisease:Haploinsufficiency of CLDN3 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
Subcellular Locationintegral component of plasma membrane,bicellular tight junction,integral component of membrane,apicolateral plasma membrane,lateral plasma membrane,extracellular exosome,
ExpressionColon,Salivary gland,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Claudin 3 around the phosphorylation site of Tyr219. AA range:171-220
Gene NameCLDN3
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Backgroundclaudin 3(CLDN3) Homo sapiens Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-60464-Conjugate. Price: $485 / Size: 100μl.
E20-60464-FITC$485 / 100μlE20-60464-Biotin$485 / 100μlE20-60464-HRP$485 / 100μlE20-60464-AP$485 / 100μlE20-60464-AF350$485 / 100μlE20-60464-AF405M$485 / 100μlE20-60464-AF488$485 / 100μlE20-60464-AF514$485 / 100μlE20-60464-AF532$485 / 100μlE20-60464-AF555$485 / 100μlE20-60464-AF568$485 / 100μlE20-60464-AF405S$485 / 100μlE20-60464-AF405L$485 / 100μlE20-60464-AF546$485 / 100μlE20-60464-AF594$485 / 100μlE20-60464-AF610$485 / 100μlE20-60464-AF635$485 / 100μlE20-60464-AF647$485 / 100μlE20-60464-AF680$485 / 100μlE20-60464-AF700$485 / 100μlE20-60464-AF750$485 / 100μlE20-60464-AF790$485 / 100μlE20-60464-APC$485 / 100μlE20-60464-PE$485 / 100μlE20-60464-Cy3$485 / 100μlE20-60464-Cy5$485 / 100μlE20-60464-Cy5.5$485 / 100μlE20-60464-Cy7$485 / 100μlE20-60464-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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