You are here: EnoGene Home > Products > Cell Signal Transduction Research Antibodies > Paxillin (phospho Ser178) Polyclonal Antibody
Paxillin (phospho Ser178) Polyclonal Antibody
Datasheet
Catalog Number:
E20-60453Amount:
100ulSwiss-Prot No.:
P49023/Q8VI36/ Q66H76Molecular Weight:
64533，Observed Band : 65kdPrice:
225$Applications:
WB,ELISAReactivity:
Human,Rat,MousePurification:
The antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogenImmunogen:
Synthesized phospho-peptide around the phosphorylation site of human Paxillin
(phospho Ser178)Specificity/Sensitivity:
Phospho-Paxillin (S178) Polyclonal Antibody detects endogenous levels of
Paxillin protein only when phosphorylated at S178.Storage/Stability:
-20°C/1 yearSource:
Polyclonal, RabbitGene Name:
PXNDilution:
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in otherBackground:
paxillin(PXN) Homo sapiens This gene encodes a cytoskeletal protein involved
in actin-membrane attachment at sites of cell adhesion to the extracellular matrix
(focal adhesion). Alternatively spliced transcript variants encoding different
isoforms have been described for this gene. These isoforms exhibit differentGene ID:
5829/ 19303/ 360820Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azideExpression:
pattern, and have different biochemical, as well as physiologicalproperties (PMID:9054445). [provided by RefSeq, Aug 2011],Function:
Cytoskeletal protein involved in actin-membrane attachment at sites ofcell adhesion to the extracellular matrix (focal adhesion).,PTM:Phosphorylated ontyrosine residues during integrin-mediated cell adhesion, embryonic development,fibroblast transformation and following stimulation of cells bymitogens.,similarity:Belongs to the paxillin family.,similarity:Contains 3 LIM zincbinding domains.,similarity:Contains 4 LIM zinc-binding domains.,subunit:Binds invitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosinephosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focaladhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but onlyweakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVAand TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1,ARHGEF6 and PAK1 (By similarity). Binds ASAP2.
Related Products
- PTEN (Phospho-Ser380) Antibody Datasheet
Catalog Number:
E011009-1Amount:
50μg/50μlReactivity:
Human, Mouse, RatApplications:
IHC: 1:50~1:100Swiss-Prot No.:
P60484Price:
145$
- PTEN (Phospho-Ser380) Antibody Datasheet
Catalog Number:
E011009-2Amount:
100μg/100μlReactivity:
Human, Mouse, RatApplications:
IHC: 1:50~1:100Swiss-Prot No.:
P60484Price:
225$
- NFκB-p65 (Phospho-Ser468) Antibody Datasheet
Catalog Number:
E011013-1Amount:
50μg/50μlReactivity:
Human, Mouse, RatApplications:
WB: 1:500~1:1000 IF:1:100~1:200Swiss-Prot No.:
Q04206Price:
145$
- NFκB-p65 (Phospho-Ser468) Antibody Datasheet
Catalog Number:
E011013-2Amount:
100μg/100μlReactivity:
Human, Mouse, RatApplications:
WB: 1:500~1:1000 IF:1:100~1:200Swiss-Prot No.:
Q04206Price:
225$
- Rel (Phospho-Ser503) Antibody Datasheet
Catalog Number:
E011020-1Amount:
50μg/50μlReactivity:
HumanApplications:
IF:1:100~1:200Swiss-Prot No.:
Q04864Price:
145$
Catalog Number
- Amount:100ul
- Price:225$
Contact us
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits