HP1γ (phospho Ser93) Polyclonal Antibody

Name: HP1γ (phospho Ser93) Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-60450
Price: 225 USD
Availability: InStock

E20-60450Cite ID: EN0049376Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight20811DaObserved Band:24KD

Protein NameChromobox protein homolog 3

Human Gene Id11335/653972

Human Swiss Prot NoQ13185

Mouse Swiss Prot NoP23198

SpecificityPhospho-HP1γ (S93) Polyclonal Antibody detects endogenous levels of HP1γ protein only when phosphorylated at S93.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameCBX3; Chromobox protein homolog 3; HECH; Heterochromatin protein 1 homolog gamma; HP1 gamma; Modifier 2 protein

Functionfunction:Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.,PTM:Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.,similarity:Contains 2 chromo domains.,subcellular location:Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis.,subunit:Binds directly to CHAF1A. Interacts with histone H3 methylated at 'Lys-9'. Part of the E2F6.com-1 complex in G0 phase composed of E2F

Subcellular Locationchromosome, centromeric region,condensed chromosome, centromeric region,nuclear chromosome, telomeric region,chromatin,nucleus,nuclear envelope,nuclear inner membrane,nuclear euchromatin,nuclear heterochromatin,spindle,nuclear pericentric heteroch

ExpressionBone marrow,Brain,Cajal-Retzius cell,Epithelium,Liver,Placenta,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from human HP1 gamma around the phosphorylation site of Ser93. AA range:59-108

Gene NameCBX3

DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Backgroundchromobox 3(CBX3) Homo sapiens At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-60450-Conjugate. Price: $485 / Size: 100μl.

E20-60450-FITC$485 / 100μlE20-60450-Biotin$485 / 100μlE20-60450-HRP$485 / 100μlE20-60450-AP$485 / 100μlE20-60450-AF350$485 / 100μlE20-60450-AF405M$485 / 100μlE20-60450-AF488$485 / 100μlE20-60450-AF514$485 / 100μlE20-60450-AF532$485 / 100μlE20-60450-AF555$485 / 100μlE20-60450-AF568$485 / 100μlE20-60450-AF405S$485 / 100μlE20-60450-AF405L$485 / 100μlE20-60450-AF546$485 / 100μlE20-60450-AF594$485 / 100μlE20-60450-AF610$485 / 100μlE20-60450-AF635$485 / 100μlE20-60450-AF647$485 / 100μlE20-60450-AF680$485 / 100μlE20-60450-AF700$485 / 100μlE20-60450-AF750$485 / 100μlE20-60450-AF790$485 / 100μlE20-60450-APC$485 / 100μlE20-60450-PE$485 / 100μlE20-60450-Cy3$485 / 100μlE20-60450-Cy5$485 / 100μlE20-60450-Cy5.5$485 / 100μlE20-60450-Cy7$485 / 100μlE20-60450-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.