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UROC28 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60429

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human PAK2 around the phosphorylation site of Ser192. AA range:158-207

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    PAK2

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

  • Western blot analysis of lysates from HeLa cells, using PAK2 (Phospho-Ser192) Antibody. The lane on the right is blocked with the phospho peptide.

  • Background:

    p21 (RAC1) activated kinase 2(PAK2) Homo sapiens The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Serine/threonine-protein kinase PAK 2

  • Human Gene Id:

    5062

  • Human Swiss Prot No:

    Q13177

  • Mouse Gene Id:

    224105

  • Mouse Swiss Prot No:

    Q8CIN4

  • Rat Gene Id:

    1.00911e+008

  • Rat Swiss Prot No:

    Q64303

  • Specificity:

    Phospho-PAKγ (S192) Polyclonal Antibody detects endogenous levels of PAKγ protein only when phosphorylated at S192.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    PAK2; Serine/threonine-protein kinase PAK 2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58

  • MolecularWeight(Da):

    58004

  • Observed Band(KD):

    58

  • Function:

    catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-402 and allows the kinase domain to adopt an active structure (By similarity). Following caspase cleavage, autophosphorylted PAK-2p34 is constitutively active.,function:The activated kinase acts on a variety of targets. Phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase-activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated for

  • Subcellular Location:

    nucleoplasm,cytoplasm,cytosol,plasma membrane,cell-cell adherens junction,perinuclear region of cytoplasm,

  • Expression:

    Epithelium,Placenta,Platelet,Tongue,

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Catalog Number

  • Amount:100ul
  • Price:225$

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UROC28 Polyclonal Antibody | EnoGene Biotech Co. Ltd