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Rad51 (phospho Tyr315) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60376

  • Amount:

    100ul

  • Swiss-Prot No.:

    Q06609/Q08297

  • Molecular Weight:

    36966，Observed Band : 37kd

  • Applications:

    WB,IHC-p,IF(paraffin section),ELISA

  • Reactivity:

    Human,Mouse

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinitychromatography using epitope-specific immunogen

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human
    RAD51 around the phosphorylation site of Tyr315. AA range:281-330

  • Specificity/Sensitivity:

    Phospho-Rad51 (Y315) Polyclonal Antibody detects endogenous levels of
    Rad51 protein only when phosphorylated at Y315.

  • Storage/Stability:

    -20°C/1 year

  • Source:

    Rabbit

  • Gene Name:

    RAD51

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA:
    1/10000. Not yet tested in other applications.

  • Background:

    RAD51 recombinase(RAD51) Homo sapiens The protein encoded by this gene
    is a member of the RAD51 protein family. RAD51 family members are highly
    similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known
    to be involved in the homologous recombination and repair of DNA. This protein
    can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to
    play roles in homologous pairing and strand transfer of DNA. This protein is also
    found to interact with BRCA1 and BRCA2, which may be important for the cellular
    response to DNA damage. BRCA2 is shown to regulate both the intracellular
    localization and DNA-binding ability of this protein. Loss of these controls
    following BRCA2 inactivation may be a key event leading to genomic instability
    and tumorigenesis. Multiple transcript variants encoding different isoforms have
    been found for this gene. [provided by RefSeq, Aug 2009],

  • Gene ID:

    5888/19361

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Function:

    disease:Defects in RAD51 are associated with breast cancer (BC)
    [MIM:114480].,function:May participate in a common DNA damage response

  • Pathway:

    associated with the activation of homologous recombination and doublestrand break repair. Binds to single and double stranded DNA and exhibits DNAdependent ATPase activity. Underwinds duplex DNA and forms helicalnucleoprotein filaments.,PTM:Phosphorylated. Phosphorylation of Thr-309 by
    CHEK1/CHK1 may enhance association with chromatin at sites of DNA damage
    and promote DNA repair by homologous recombination.,similarity:Belongs to the
    recA family.,similarity:Belongs to the recA family. RAD51
    subfamily.,similarity:Contains 1 HhH domain.,subcellular location:Colocalizes with
    RAD51AP1 to multiple nuclear foci upon induction of DNA
    damage.,subunit:Interacts with BRCA1, BRCA2 and either directly or indirectly
    with p53. Interacts with XRCC3, RAD54L an

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Catalog Number

  • Amount:100ul
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Rad51 (phospho Tyr315) Polyclonal Antibody | EnoGene Biotech Co. Ltd