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NFATc4 (phospho Ser676) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60313

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human NFAT3 around the phosphorylation site of Ser676. AA range:642-691

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    NFATC4

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Western blot analysis of lysates from HepG2 cells treated with Ca2+ 40uM 30', using NFAT3 (Phospho-Ser676) Antibody. The lane on the right is blocked with the phospho peptide.

  • Background:

    nuclear factor of activated T-cells 4(NFATC4) Homo sapiens This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],

  • Protein Name:

    Nuclear factor of activated T-cells cytoplasmic 4

  • Human Gene Id:

    4776

  • Human Swiss Prot No:

    Q14934

  • Mouse Gene Id:

    73181

  • Mouse Swiss Prot No:

    Q8K120

  • Specificity:

    Phospho-NFATc4 (S676) Polyclonal Antibody detects endogenous levels of NFATc4 protein only when phosphorylated at S676.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    NFATC4; NFAT3; Nuclear factor of activated T-cells; cytoplasmic 4; NF-ATc4; NFATc4; T-cell transcription factor NFAT3; NF-AT3

  • MolecularWeight(Da):

    95473

  • Observed Band(KD):

    120

  • Function:

    domain:Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.,function:Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.,PTM:Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin. Phosphorylated on Ser-168 and Ser-170 by FRAP1, IRAK1, MAPK7 and MAPK14, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and on Ser-289 and Ser-344 by RPS6KA3. Phosphorylated by GSK3B.,PTM:Ubiquitinated, leading

  • Subcellular Location:

    nucleus,transcription factor complex,cytoplasm,cytosol,intermediate filament cytoskeleton,

  • Expression:

    Adrenal gland,Epithelium,Ovary,Rhabdomyosarcoma,T-cell,Testis,

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Catalog Number

  • Amount:100ul
  • Price:225$

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