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MITF (phospho Ser180) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60310

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human MITF around the phosphorylation site of Ser180/73. AA range:151-200

  • Source:

    Polyclonal, Rabbit

  • Gene Name:

    MITF

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

  • Western blot analysis of lysates from COS7 cells, using MITF (Phospho-Ser180/73) Antibody. The lane on the right is blocked with the phospho peptide.

  • Background:

    melanogenesis associated transcription factor(MITF) Homo sapiens This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Microphthalmia-associated transcription factor

  • Human Gene Id:

    4286

  • Human Swiss Prot No:

    O75030

  • Mouse Gene Id:

    17342

  • Mouse Swiss Prot No:

    Q08874

  • Specificity:

    Phospho-MITF (S180) Polyclonal Antibody detects endogenous levels of MITF protein only when phosphorylated at S180.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    MITF; BHLHE32; Microphthalmia-associated transcription factor; Class E basic helix-loop-helix protein 32; bHLHe32

  • MolecularWeight(Da):

    58795

  • Observed Band(KD):

    52

  • Function:

    alternative products:The X2-type isoforms differ from the X1-type isoforms by the absence of a 6 residue insert,disease:Defects in MITF are a cause of Waardenburg syndrome type 2 with ocular albinism (WS2-OA) [MIM:103470]. It is an ocular albinism with sensorineural deafness.,disease:Defects in MITF are the cause of Tietz syndrome [MIM:103500]. It is an autosomal dominant disorder characterized by generalized hypopigmentation and profound, congenital, bilateral deafness. Penetrance is complete.,disease:Defects in MITF are the cause of Waardenburg syndrome type 2A (WS2A) [MIM:193510]. It is a dominant inherited disorder characterized by sensorineural hearing loss and patches of depigmentation. The features show variable expression and penetrance.,function:Transcription factor for tyrosinase and tyrosinase-related protein 1. Binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') foun

  • Subcellular Location:

    nucleus,nucleoplasm,protein complex,

  • Expression:

    Blood,Kidney,Skin,Uterus,

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Catalog Number

  • Amount:100ul
  • Price:225$

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MITF (phospho Ser180) Polyclonal Antibody | EnoGene Biotech Co. Ltd