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JAK2 (phospho Tyr570) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60306

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human JAK2 around the phosphorylation site of Tyr570. AA range:541-590

  • Source:

    Polyclonal, Rabbit

  • Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100(4° overnight). High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

  • Gene Name:

    JAK2

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

  • Background:

    Janus kinase 2(JAK2) Homo sapiens This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008],

  • Protein Name:

    Tyrosine-protein kinase JAK2

  • Human Gene Id:

    3717

  • Human Swiss Prot No:

    O60674

  • Mouse Gene Id:

    16452

  • Mouse Swiss Prot No:

    Q62120

  • Rat Gene Id:

    24514

  • Rat Swiss Prot No:

    Q62689

  • Specificity:

    Phospho-JAK2 (Y570) Polyclonal Antibody detects endogenous levels of JAK2 protein only when phosphorylated at Y570.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2

  • MolecularWeight(Da):

    130674

  • Observed Band(KD):

    130

  • Function:

    catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Chromosomal aberrations involving JAK2 are found in both chronic and acute forms of eosinophilic, lymphoblastic and myeloid leukemia. Translocation t(8;9)(p22;p24) with PCM1 links the protein kinase domain of JAK2 to the major portion of PCM1. Translocation t(9;12)(p24;p13) with ETV6.,disease:Defects in JAK2 are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.,disease:Defects in JAK2 are a cause of susceptibility to Budd-Chiari syndrome [MIM:600880]. Budd-Chiari syndrome is a spectrum of disease states, including anatomic abnormalities and hypercoagulable disorders, resulting in hepatic venous outflow occlusion. Clinical manifestations observed in the majority of patients incl

  • Subcellular Location:

    nucleus,nucleoplasm,cytoplasm,cytosol,cytoskeleton,caveola,membrane,nuclear matrix,extrinsic component of cytoplasmic side of plasma membrane,endosome lumen,membrane raft,

  • Expression:

    Fetal brain,Uterus,

  • Western blot analysis of lysates from 293 cells treated with etoposide 25uM 24h, using JAK2 (Phospho-Tyr570) Antibody. The lane on the right is blocked with the phospho peptide.

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Catalog Number

  • Amount:100ul
  • Price:225$

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JAK2 (phospho Tyr570) Polyclonal Antibody | EnoGene Biotech Co. Ltd