CREB-1 (phospho Ser121) Polyclonal Antibody

Name: CREB-1 (phospho Ser121) Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-60303
Price: 225 USD
Availability: InStock

E20-60303Cite ID: EN0049229Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight36688Da

Protein NameCyclic AMP-responsive element-binding protein 1

Human Gene Id1385

Human Swiss Prot NoP16220

Mouse Gene Id12912

Mouse Swiss Prot NoQ01147

Rat Gene Id81646

Rat Swiss Prot NoP15337

SpecificityPhospho-CREB-1 (S121) Polyclonal Antibody detects endogenous levels of CREB-1 protein only when phosphorylated at S121.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameCREB1; Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1

Observed Band(KD)43

Functiondisease:A chromosomal aberration involving CREB1 is associated with angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type.,function:This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transciption activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.,PTM:Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarit

Subcellular Locationnuclear chromatin,nucleus,nucleoplasm,nuclear euchromatin,mitochondrial matrix,axon,ATF4-CREB1 transcription factor complex,

ExpressionEye,Placenta,Spleen,Testis,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from human CREB around the phosphorylation site of Ser121. AA range:91-140

Gene NameCREB1

DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

BackgroundcAMP responsive element binding protein 1(CREB1) Homo sapiens This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],

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Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-60303-Conjugate. Price: $485 / Size: 100μl.

E20-60303-FITC$485 / 100μlE20-60303-Biotin$485 / 100μlE20-60303-HRP$485 / 100μlE20-60303-AP$485 / 100μlE20-60303-AF350$485 / 100μlE20-60303-AF405M$485 / 100μlE20-60303-AF488$485 / 100μlE20-60303-AF514$485 / 100μlE20-60303-AF532$485 / 100μlE20-60303-AF555$485 / 100μlE20-60303-AF568$485 / 100μlE20-60303-AF405S$485 / 100μlE20-60303-AF405L$485 / 100μlE20-60303-AF546$485 / 100μlE20-60303-AF594$485 / 100μlE20-60303-AF610$485 / 100μlE20-60303-AF635$485 / 100μlE20-60303-AF647$485 / 100μlE20-60303-AF680$485 / 100μlE20-60303-AF700$485 / 100μlE20-60303-AF750$485 / 100μlE20-60303-AF790$485 / 100μlE20-60303-APC$485 / 100μlE20-60303-PE$485 / 100μlE20-60303-Cy3$485 / 100μlE20-60303-Cy5$485 / 100μlE20-60303-Cy5.5$485 / 100μlE20-60303-Cy7$485 / 100μlE20-60303-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.