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HDAC2 (phospho Ser394) Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-60282

  • Amount:

    100ul

  • Molecular Weight:

    55364Da

  • Applications:

    WB;ELISA

  • Reactivity:

    Human;Mouse;Rat;Monkey

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human HDAC2 around the phosphorylation site of Ser394. AA range:360-409

  • Source:

    Polyclonal, Rabbit,IgG

  • Western Blot analysis of 3T3 cells using Phospho-HDAC2 (S394) Polyclonal Antibody

  • Gene Name:

    HDAC2

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

  • Background:

    This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010],

  • Protein Name:

    Histone deacetylase 2

  • Human Gene Id:

    3066

  • Human Swiss Prot No:

    Q92769

  • Mouse Gene Id:

    15182

  • Mouse Swiss Prot No:

    P70288

  • Specificity:

    Phospho-HDAC2 (S394) Polyclonal Antibody detects endogenous levels of HDAC2 protein only when phosphorylated at S394.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    HDAC2; Histone deacetylase 2; HD2

  • Observed Band(KD):

    55

  • Function:

    catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,sequence caution:Intron retention.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Interacts with the non-histone region of H2AFY (By similarity

  • Subcellular Location:

    Nucleus . Cytoplasm .

  • Expression:

    Widely expressed; lower levels in brain and lung.

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Catalog Number

  • Amount:100ul
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HDAC2 (phospho Ser394) Polyclonal Antibody | EnoGene Biotech Co. Ltd